Liquid Biopsy

Liquid biopsy is a test done on a blood sample, to look for circulating tumour cells (CTC) or pieces of circulating tumour DNA (ctDNA) shed by cancer cells in the blood of a patient. Procedure is rather safe, simple, fast and cost effective, which only involves the extraction of patients’ blood.

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Next Generation Sequencing (NGS)

Next generation sequencing (NGS) is a new method in genome/ DNA sequencing, with improved accuracy and speed. NGS is used to examine and detect DNA mutations, copy number variations and gene fusions across the genome. In most cases, cancer usually involves mutations in multiple genes. Therefore, looking at single gene mutation is often insufficient for targeted therapy.

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PCR and Fragment Analysis

Polymerase Chain Reaction (PCR) is a technique used to amplify a specific piece of DNA or RNA from a sample. PCR can be used to detect certain chances in gene or chromosome. Fragment analysis is a genetic marker analysis which rely on the detection of the changes in the length of a specific DNA sequence to indicate the presence of absence of a genetic marker.

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Multiplex Ligation-Dependent Probe Amplification (MLPA)

Multiplex Ligation-dependent Probe Amplification (MLPA) is a multiplex PCR method detecting abnormal copy numbers of specific genes, including small intragenic rearrangements for up to 50 different genomic DNA or RNA sequences. MLPA is a very important technique in the assessment of hereditary diseases including cancers.

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Automated and Powerful Pipelines

In ONCODE, all the pipelines are fully automated in order to minimise human, instrumentation or technical errors as well as reducing accidents and risks. In order to ensure highest accuracy and minimization of instrumentation errors, ONCODE workflows follow the following practices

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