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ONCODEduce AML Combo

Comprehensive Package for AML detecting 24 gene mutation and fusion commonly implicated in AML to provide possible prognostic, therapeutic and diagnostic options

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ONCODEduce AML Core

NGS panel targeting 13 gene mutations commonly altered in AML including FLT3-ITD & TKD, NPM1, CEBPA, IDH1/2, KIT, RUNX1, TP53 and more

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ONCODEduce MDS Mutation 37-gene

NGS panel targeting 37 gene mutations that allows a broader exploration of the genes implicated in MDS for diagnosis, prognosis and therapeutic options

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ONCODEduce ABL1 Kinase Domain Mutation

NGS panel to detect Tyrosine Kinase Inhibitors (TKIs) resistance mutations in ABL1 kinase domain and BCR-ABL1 fusions

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ONCODEduce ALL Fusion 87 gene

NGS panel detecting 87 gene fusions implicated in B-ALL including fusions identifying Ph-like BCR-ABL1 negative B-ALL

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ONCODEduce Eosinophilia Fusion

NGS panel to detect all fusions in PDGFRA (including FIP1L1-PDGFRA), PDGFRB, FGFR1, BCR, ABL1, FLT3, ETV6 and JAK2 (including PCM1 JAK2)

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ONCODEduce MPN PCR

PCR-based test for the detection of mutations in JAK2 V617F & exon 12, CALR, MPL W515K/L/A & S505N

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ONCODEduce AML Combo (Mutation & Fusion) NGS Panel

Product Description:

Comprehensive package for AML for the diagnosis, prognostic, and therapy selection targeting genes mutations (DNA mutation) in hotspot regions/selected exons of 13 genes commonly mutated in AML, and the commonest rearrangements (RNA fusions) in 11 genes implicated in AML.

Highlighted Genes -- Mutation: FLT3-ITD & TKD, NPM1, CEBPA, IDH1/2, KIT, RUNX1, TP53, etc.; Fusion: RUNX1, CBFB, RARA, BCR, ABL1, MLL/KMT2A, etc.;

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

DNA and RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

6ml of Blood or Marrow Aspirate in EDTA tube or
4 aspirate smears with adequate cellularity

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

Contact Us

ONCODEduce AML Core NGS Panel

Product Description:

NGS Panel targeting 13 gene mutations commonly altered in AML for the diagnosis, prognostic, and therapy selection.

Highlighted Genes -- FLT3-ITD & TKD, NPM1, CEBPA, IDH1/2, KIT, RUNX1, TP53, etc.

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

DNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases. .

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

Contact Us

ONCODEduce MDS Mutation 37-gene NGS Panel

Product Description:

NGS Panel targeting 37 gene mutations that allows a broader exploration of the gene frequently implicated in the diagnosis, treatment and prognostication of MDS.

Highlighted Genes -- ASXL1, DNMT3A, EZH2, KRAS, NPM1, NRAS, RUNX1, SF3B1, SRSF2, TET2, TP53, U2AF1, ZRSR2 etc.

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

DNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

Contact Us

ONCODEduce ABL1 Kinase Domain Mutation NGS Panel

Product Description:

NGS Panel to detect Tyrosine Kinase Inhibitors (TKIs) resistance mutations in ABL1 kinase domain and BCR-ABL1 fusions.

Gene Covered -- BCR-ABL1 fusion and mutation in ABL1 kinase domain (amino acid positions 244-396)

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. This assay is designed to capture the fusion event from both ends, enabling independent detection of a single fusion event, and resulting in an internal, orthogonal verification of these fusions. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

Contact Us

ONCODEduce B-ALL Fusion 87 gene NGS Panel

Product Description:

NGS Panel detecting 87 gene fusions implicated in B-ALL including fusions identifying Ph-like BCR-ABL1 negative B-ALL.

Highlighted Genes -- ABL1, ABL2, CRLF2, CSF1R, EPOR, ETV6, JAK2, KMT2A, P2RY8, PAX5, PDGFRA, PDGFRB, PTK2B, TCF3, TYK2

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. This assay is designed to capture the fusion event from both ends, enabling independent detection of a single fusion event, and resulting in an internal, orthogonal verification of these fusions. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

Contact Us

ONCODEduce Eosinophilia Fusion NGS Panel

Product Description:

NGS Panel to detect all fusions involving 8 genes: PDGFRA (including FIP1L1-PDGFRA), PDGFRB, FGFR1, BCR, ABL1, FLT3, ETV6 & JAK2 (including PCM1-JAK2).

Genes Covered-- PDGFRA, PDGFRB, ABL1, BCR, ETV6, FGFR1, FLT3 & JAK2

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. This assay is designed to capture the fusion event from both ends, enabling independent detection of a single fusion event, and resulting in an internal, orthogonal verification of these fusions. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

Contact Us

ONCODEduce MPN PCR Panel

Product Description:

Qualitative PCR based panel to detect the presence of JAK2 V617F, JAK2 exon 12, Calreticulin and MPL W515K/L/A & S505N mutations which is useful in the assessment of Myeloproliferative conditions.

Genes Covered-- JAK2 V617F & exon 12, CALR, MPL W515K/L/A & S505N mutations

Technique:

Polymerase Chain Reaction (PCR)

Test Methodology:

DNA extracted from blood/ marrow is subjected to PCR with primers targeting these hotspot regions and/or variants. JAK2 exon 12 & CALR amplicons are separated by capillary electrophoresis and identified by label and size, while JAK2 V617F & MPL amplicons are separated by agarose gel electrophoresis and identified by size.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

Contact Us