Oncode Scientific

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The conviction that drives us

Empowering Clinicians

In Oncode, we empower clinicians by providing easy-to-read genetic reports with interpretations that provide direct recommendations of next steps

Product Features

Personalized & Reader Friendly Report​

Oncode providing reader friendly, simple, colour guided report suggesting next steps based on individual patient’s clinical picture & prior therapy.

Customized Test Panel

Oncode has a range of test menu ranging from single panel target distinguished diseases specifically to comprehensive panel specifically for the state of advanced disease specially designed to suit your needs

Highly Reliable and Accurate Result

Oncode lab participates in external quality assurance and proficiency programs including UKNEQAS, EMQN, RCPA and CAP to ensure high quality result at all time

Quick Turnaround Time

100% achieving promised turnaround time till date

Star Products

  • Solid Tumors
  • Blood Cancers

ONCODEcipher Liquid28

Non-invasive NGS panel targeting 28 genes mutation using liquid biopsy (blood) to provide treatment options & prognostic indications

 

 

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ONCODEcipher Lung Absolute 2.0

NGS panel targeting 14 genes commonly altered in lung cancer including fusions (ALK, ROS1, MET, RET, NTRK etc.) and mutations (EGFR, KRAS, BRAF, ALK, ERBB2 etc.)

 

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ONCODEcipher Breast & Ovarian Core28

NGS panel targeting 28 clinically relevant and actionable genes commonly mutated in ALL solid tumours including BRCA1 & 2 (somatic), ESR1, PIK3CA, TP53 and others

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ONCODEcipher Colon Essential67 + MSI

NGS panel targeting 67 relevant genetic mutations (including mutations of RAS/RAF/MEK/MAP kinase signaling pathway) AND microsatellite instability status using tissue biopsy

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ONCODEcipher Microsatellite Instability (MSI)

PCR & Fragment analysis-based assays detecting microsatellite instability status for the discovery of treatment options

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ONCODEcipher BRCA 1&2 Germline + MLPA

NGS panel targeting germline BRCA 1 & 2 mutations (100% coverage) to identify the risk of hereditary breast, ovarian, prostate, pancreatic cancers; and to seek for treatment options

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ONCODEcipher BRAF PCR

PCR-based method to detect BRAF mutation at V600E hotpot in all solid tumours especially in melanoma

 

 

Learn More

ONCODEduce AML Combo

Comprehensive Package for AML detecting 24 gene mutation and fusion commonly implicated in AML to provide possible prognostic, therapeutic and diagnostic options

ONCODEduce AML Core

NGS panel targeting 13 gene mutations commonly altered in AML including FLT3-ITD & TKD, NPM1, CEBPA, IDH1/2, KIT, RUNX1, TP53 and more

ONCODEduce MDS Mutation 37-gene

NGS panel targeting 37 gene mutations that allows a broader exploration of the genes implicated in MDS for diagnosis, prognosis and therapeutic options

ONCODEduce ABL1 Kinase Domain Mutation

NGS panel to detect Tyrosine Kinase Inhibitors (TKIs) resistance mutations in ABL1 kinase domain and BCR-ABL1 fusions

ONCODEduce ALL Fusion 87 gene

NGS panel detecting 87 gene fusions implicated in B-ALL including fusions identifying Ph-like BCR-ABL1 negative B-ALL

ONCODEduce Eosinophilia Fusion

NGS panel to detect all fusions in PDGFRA (including FIP1L1-PDGFRA), PDGFRB, FGFR1, BCR, ABL1, FLT3, ETV6 and JAK2 (including PCM1 JAK2)

ONCODEduce MPN PCR

PCR-based test for the detection of mutations in JAK2 V617F & exon 12, CALR, MPL W515K/L/A & S505N

How to order

Oncode Scientific Sdn Bhd provides a one stop solution for all your inquiries, questions and ordering needs. We are always available to assist you in all aspects of the testing process.

CLINICIANS

  1. Receive Specimen Collection Kit from Oncode
  2. Fill up the Test Requisition Form
  3. Draw patient’s blood into EDTA/ Streck tubes AND/OR prepare FFPE slides/ block

COURIER

  1. Picks up kit and delivers to Oncode laboratory at room temperature

ONCODE

  1. Quantify and qualify sample
  2. Perform test accordingly
  3. Generate and send reports to clinician within stated turnaround time

CLINICIANS

  1. Interpret report to patient
  2. Proceed with treatments and/or subsequent test

CLINICIANS

1. Receive Specimen Collection Kit from Oncode

2. Fill up the Test Requisition Form

3. Draw patient’s blood into EDTA/ Streck tubes AND/OR prepare FFPE slides/ block

COURIER

4. Picks up kit and delivers to Oncode laboratory at room temperature

ONCODE

5. Quantify and qualify sample

6. Perform test accordingly

7. Generate and send reports to clinician within stated turnaround time

CLINICIANS

8. Interpret report to patient

9.Proceed with treatments and/or subsequent test

CLINICIANS

  1. Receive Specimen Collection Kit from Oncode
  2. Fill up the Test Requisition Form
  3. Draw patient’s blood into EDTA/ Streck tubes AND/OR prepare FFPE slides/ block

COURIER

  1. Picks up kit and delivers to Oncode laboratory at room temperature

ONCODE

  1. Quantify and qualify sample
  2. Perform test accordingly
  3. Generate and send reports to clinician within stated turnaround time

CLINICIANS

  1. Interpret report to patient
  2. Proceed with treatments and/or subsequent test

GET ONE NOW!

Oncode Specimen Collection Kit

Oncode Specimen Collection Kit containing:

  • Specimen collection tube(s) or container(s)
  • Test Requisition Form
  • Courier form

Kindly fill up Test Requisition Form upon sample pick-up/ delivery. Patient’s pathology reports or clinical reports (if any) can be attached altogether.
(Refer to Oncode Product page for information on sample type and amount).

GET ONE NOW!

Oncode Specimen Collection Kit

Oncode Specimen Collection Kit containing:

  • Specimen collection tube(s) or container(s)
  • Test Requisition Form
  • Courier form

Kindly fill up Test Requisition Form upon sample pick-up/ delivery. Patient’s pathology reports or clinical reports (if any) can be attached altogether.
(Refer to Oncode Product page for information on sample type and amount).

Frequently asked questions

  • Oncode specialize in molecular diagnostics especially in the area of cancer for both solid tumours and blood cancer
  • Oncode provides complete solutions from consultation on what test to do, to molecular lab testing, follow by the analysis and interpretation of data generated, to the issuing of comprehensive genetic report signed by qualified laboratory personnel and pathologist.
  • We have tests that:
    1. allow comprehensive coverage specifically for the state of advanced disease
    2. target distinguished diseases specifically

Tissue biopsy should always be prioritized whenever possible as it represents the local tumour content and would provide important information as a reference. However liquid biopsy is applicable especially:

  • For monitoring of the responses to treatment and help explain why some cancers are resistant to therapies
  • When a tissue biopsy is challenging in that it is costly, painful or potentially risky for the patient
  • When tissue biopsy is non-accessible in some advanced cancers
  • When multiple samples are required to help doctors to understand what kind of molecular changes are taking place in a tumour
  • Oncode offers molecular genetic tests which provide information on genetic mutations, rate of distinguished mutations, drug applications, drug indications and drug resistance.
  • However, it is not recommended to use molecular test as a diagnosis for cancer type.
  • Generally, cancer should be diagnosed and categorized by histopathological grading and staining to conclude the grade of a particular cancer and cancer type, prior to be subjected for molecular testing.
  • Both histopathology and molecular testing play different important roles at different stages of diagnosis process. Both are equally important and it is not recommended to skip either one, or using one to replace another.
  • All the tests performed in Oncode can be performed either by using blood (for liquid biopsy panel or blood cancer panel) or using formalin-fixed, paraffin-embedded (FFPE) tissues.

Genetic counsellor is available for consultation upon request.

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ONCODEcipher Liquid28 NGS Panel

Product Description:

Non-invasive cell free circulating tumour DNA (ctDNA) panel that delivers information on a variety of treatment/prognosis informative mutations in the 28 genes which are known to play a role in of solid tumours using only the blood of the patients.

Highlighted Genes -- EGFR, BRAF, KRAS, ESR1, FGFR, PIK3CA, TP53, ALK resistance etc.

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

Cell free DNA extracted from plasma is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

15ml Blood in cfDNA tubes

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEcipher Lung Absolute 2.0 NGS Panel

Product Description:

FFPE TNA panel targeting both fusions and mutations in 15 genes commonly altered in lung cancer to provide treatment options & prognostic indications.

Highlighted Genes -- Fusion: ALK, ROS1, MET, NTRK, etc.; Mutation: EGFR, ERBB2, BRAF, KRAS, etc.

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

Total Nucleic Acid extracted from FFPE tissue is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial clinical bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

FFPE tissue (FFPE block or 10 unstained slides [10µm thickness] with minimal surface area of 5mm2 and at least 30% tumour cellularity) & 1 H&E stained slide

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEcipher Breast & Ovarian Core28 NGS Panel

Product Description:

FFPE DNA panel targeting 28 clinically relevant and actionable genes commonly mutated in breast & ovarian cancer to provide treatment options & prognostic indications.

Highlighted Genes -- Somatic BRCA1 & BRCA2, ESR1, PIK3CA, TP53, etc.

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

DNA extracted from FFPE tissue is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial clinical bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

FFPE tissue (FFPE block or 10 unstained slides [10µm thickness] with minimal surface area of 5mm2 and at least 30% tumour cellularity) & 1 H&E stained slide

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEcipher Colon Essential67 + MSI Panel

Product Description:

FFPE DNA panel targeting 67 relevant genetic mutations in colon cancer AND microsatellite instability (MSI) status to provide treatment options & prognostic indications.

Highlighted Genes -- Mutations of RAS/ RAF/ MEK/ MAP kinase signalling pathway

Technique:

Next Generation Sequencing (NGS) AND
Polymerase Chain Reaction (PCR) & Fragment Analysis

Test Methodology:

Essential 67 NGS Panel
DNA extracted from FFPE tissue is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial clinical bioinformatics pipelines and annotation is done using proprietary and public databases.

MSI PCR & Fragment Analysis Panel
DNA extracted from FFPE tissue (tumour) & blood (non-tumour) is subjected to PCR & amplicons are separated and identified by fragment analysis. The pattern of amplicons for the 5 mononucleotide markers is compared between tumour and non-tumour.

Specimen Requirements:

FFPE tissue (FFPE block or 10-15 unstained slides [10µm thickness] with minimal surface area of 5mm2 and at least 30% tumour cellularity) & 1 H&E stained slide
AND 3ml Blood in EDTA tube(s)

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEcipher Microsatellite Instability (MSI) PCR Panel

Product Description:

PCR and fragment analysis-based assay targeting MSI to detect the increase in length of the microsatellite segment by comparing microsatellite allele size variations between normal and tumour samples in five mononucleotide repeat markers for the discovery of treatment options such as immunotherapy.

Target Markers -- NR-21, NR-24, BAT-26, BAT-25, & MONO-27

Technique:

Polymerase Chain Reaction (PCR) & Fragment Analysis

Test Methodology:

DNA extracted from FFPE tissue (tumour) & blood (non-tumour) is subjected to PCR & amplicons are separated and identified by fragment analysis. The pattern of amplicons for the 5 mononucleotide markers is compared between tumour and non-tumour.

Specimen Requirements:

FFPE tissue (FFPE block or 5 unstained slides [10µm thickness] with minimal surface area of 5mm2 and at least 30% tumour cellularity) & 1 H&E stained slide
AND 3ml Blood in EDTA tube(s)

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEcipher BRCA1/2 Germline NGS & MLPA Panel

Product Description:

NGS and MLPA panel targeting germline BRCA 1 & 2 mutations with 100% coverage including SNV, small InDels, large deletions & duplications, and large genomic rearrangement (LGR) to identify the risk of hereditary breast, ovarian, prostate, pancreatic cancers; and to seek for treatment options.

Genes Covered -- 100% coverage of BRCA 1 & 2 germline mutations

Technique:

Next Generation Sequencing (NGS) & Multiplex Ligation-Dependent Probe Amplification (MLPA)

Test Methodology:

NGS: DNA extracted from blood is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using proprietary bioinformatics pipelines.

MLPA: DNA extracted from blood is subjected to Multiplex Ligation-Dependent Probe Amplification. Fluorescent labelled amplicons are separated and quantified by capillary electrophoresis.

Specimen Requirements:

3ml Blood in EDTA tube(s)

TAT

Turn Around Time:

12-15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEcipher BRAF PCR Panel

Product Description:

PCR method to detect BRAF mutation at V600E hotspot in all solid tumours especially in melanoma to provide treatment options.

Gene Covered -- BRAF V600E

Technique:

Polymerase Chain Reaction (PCR)

Test Methodology:

DNA extracted from FFPE tissue is subjected to PCR with primers targeting the hotspot region & amplicons are separated and identified by agarose gel electrophoresis.

Specimen Requirements:

FFPE tissue (FFPE block or 5 unstained slides [10µm thickness] with minimal surface area of 5mm2 and at least 30% tumour cellularity) & 1 H&E stained slide

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEduce AML Combo (Mutation & Fusion) NGS Panel

Product Description:

Comprehensive package for AML for the diagnosis, prognostic, and therapy selection targeting genes mutations (DNA mutation) in hotspot regions/selected exons of 13 genes commonly mutated in AML, and the commonest rearrangements (RNA fusions) in 11 genes implicated in AML.

Highlighted Genes -- Mutation: FLT3-ITD & TKD, NPM1, CEBPA, IDH1/2, KIT, RUNX1, TP53, etc.; Fusion: RUNX1, CBFB, RARA, BCR, ABL1, MLL/KMT2A, etc.;

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

DNA and RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

6ml of Blood or Marrow Aspirate in EDTA tube or
4 aspirate smears with adequate cellularity

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEduce AML Core NGS Panel

Product Description:

NGS Panel targeting 13 gene mutations commonly altered in AML for the diagnosis, prognostic, and therapy selection.

Highlighted Genes -- FLT3-ITD & TKD, NPM1, CEBPA, IDH1/2, KIT, RUNX1, TP53, etc.

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

DNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases. .

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

10 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEduce MDS Mutation 37-gene NGS Panel

Product Description:

NGS Panel targeting 37 gene mutations that allows a broader exploration of the gene frequently implicated in the diagnosis, treatment and prognostication of MDS.

Highlighted Genes -- ASXL1, DNMT3A, EZH2, KRAS, NPM1, NRAS, RUNX1, SF3B1, SRSF2, TET2, TP53, U2AF1, ZRSR2 etc.

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

DNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEduce ABL1 Kinase Domain Mutation NGS Panel

Product Description:

NGS Panel to detect Tyrosine Kinase Inhibitors (TKIs) resistance mutations in ABL1 kinase domain and BCR-ABL1 fusions.

Gene Covered -- BCR-ABL1 fusion and mutation in ABL1 kinase domain (amino acid positions 244-396)

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. This assay is designed to capture the fusion event from both ends, enabling independent detection of a single fusion event, and resulting in an internal, orthogonal verification of these fusions. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEduce B-ALL Fusion 87 gene NGS Panel

Product Description:

NGS Panel detecting 87 gene fusions implicated in B-ALL including fusions identifying Ph-like BCR-ABL1 negative B-ALL.

Highlighted Genes -- ABL1, ABL2, CRLF2, CSF1R, EPOR, ETV6, JAK2, KMT2A, P2RY8, PAX5, PDGFRA, PDGFRB, PTK2B, TCF3, TYK2

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. This assay is designed to capture the fusion event from both ends, enabling independent detection of a single fusion event, and resulting in an internal, orthogonal verification of these fusions. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEduce Eosinophilia Fusion NGS Panel

Product Description:

NGS Panel to detect all fusions involving 8 genes: PDGFRA (including FIP1L1-PDGFRA), PDGFRB, FGFR1, BCR, ABL1, FLT3, ETV6 & JAK2 (including PCM1-JAK2).

Genes Covered-- PDGFRA, PDGFRB, ABL1, BCR, ETV6, FGFR1, FLT3 & JAK2

Technique:

Next Generation Sequencing (NGS)

Test Methodology:

RNA extracted from blood/ marrow/ aspirate smears is subjected to amplification-based library preparation and massively parallel sequencing. This assay is designed to capture the fusion event from both ends, enabling independent detection of a single fusion event, and resulting in an internal, orthogonal verification of these fusions. Sequencing analysis is performed using commercial bioinformatics pipelines and annotation is done using proprietary and public databases.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube or
2 aspirate smears with adequate cellularity

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.

ONCODEduce MPN PCR Panel

Product Description:

Qualitative PCR based panel to detect the presence of JAK2 V617F, JAK2 exon 12, Calreticulin and MPL W515K/L/A & S505N mutations which is useful in the assessment of Myeloproliferative conditions.

Genes Covered-- JAK2 V617F & exon 12, CALR, MPL W515K/L/A & S505N mutations

Technique:

Polymerase Chain Reaction (PCR)

Test Methodology:

DNA extracted from blood/ marrow is subjected to PCR with primers targeting these hotspot regions and/or variants. JAK2 exon 12 & CALR amplicons are separated by capillary electrophoresis and identified by label and size, while JAK2 V617F & MPL amplicons are separated by agarose gel electrophoresis and identified by size.

Specimen Requirements:

3ml of Blood or Marrow Aspirate in EDTA tube

TAT

Turn Around Time:

15 working days

shipment_requirement

Shipment Requirement:

Keep specimen at room temperature. DO NOT ship on ice or dry ice or expose to direct sunlight.